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- Thwarting resistance: MgrA inhibition with . . .
The current study aims to elucidate the underlying mechanism by which Mo-A exerts inhibitory effects on MgrA, offering a novel candidate compound for combating multidrug-resistant S aureus infections
- Staphylococcus aureus uses the ArlRS and MgrA cascade to . . .
In this work, we identified the ArlRS and MgrA as regulators of the virulence in MRSA skin infection, affecting both skin damage and MRSA survival in the host These effects were largely due to ArlRS and MgrA regulating MRSA immune evasion through control of virulence factor expression
- Exploring the potential of isorhapontigenin: attenuating
MgrA, a key virulence regulator in S aureus, orchestrates the expression of numerous virulence factors Here, we report the discovery of isorhapontigenin, a methoxylated analog of resveratrol, as a potential anti-virulence agent against S aureus
- Thwarting resistance: MgrA inhibition with . . . - PubMed
Subsequent analysis revealed that Mo-A effectively inhibits the expression of virulence factors such as Hla and Pvl in S aureus and markedly reduces its adhesion capability to fibrinogen On a cellular landscape, Mo-A exerts a mitigating influence on the deleterious effects inflicted by S aureus USA300 on A549 cells
- Efflux pump modulation by Montelukast and its roles in . . .
Our study showed that Montelukast repressed MgrA expression and promoted MgrA phosphorylation to suppress norB expression and efflux pump activity, leading to the restoration of antibiotic susceptibility in multidrug-resistant S aureus The study was supported by SERB-DST, India (CRG 2021 005069), and the BRIC-ILS core
- The Staphylococcus aureus Global Regulator MgrA Modulates . . .
Strains lacking mgrA fail to clump in the presence of fibrinogen, and clumping can be restored to an arlRS mutant by overexpressing either arlRS or mgrA, indicating that ArlRS and MgrA constitute a regulatory pathway
- Targeting MgrA-Mediated Virulence Regulation in . . .
We have shown that MgrA is critical for S aureus pathogenesis in vivo, and an mgrA mutant strain exhibits 1000–10,000 fold virulence reduction in a mouse model of infection (Chen et al , 2006) We have also revealed that MgrA acts as a redox-switch via its sole and unique Cys12 to regulate gene expression
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